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open access eISSN 2093-3673

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Original Article

Anat Cell Biol 2023; 56(4): 463-468

Published online December 31, 2023

https://doi.org/10.5115/acb.23.084

Copyright © Korean Association of ANATOMISTS.

Histology and immunohistochemistry of the human carotid sinus nerve

Davin Bryant1 , Erin McCormack2,3 , Juan J. Cardona2 , Arada Chaiyamoon2,4 , Devendra Shekhawat2 , Francisco Reina5 , Ana Carrera5 , Joe Iwanaga2,6,7,8 , Aaron S. Dumont2 , R. Shane Tubbs2,3,7,8,9,10,11

1Tulane University School of Medicine, New Orleans, LA, 2Department of Neurological Surgery, Tulane Center for Clinical Neurosciences, Tulane University School of Medicine, New Orleans, LA, 3Department of Neurosurgery and Ochsner Neuroscience Institute, Ochsner Health System, New Orleans, LA, USA, 4Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, 5Department of Medical Sciences, Clinical Anatomy, Embryology and Neurosciences Research Group, University of Girona, Girona, Spain, 6Department of Oral and Maxillofacial Anatomy, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, 7Department of Structural & Cellular Biology, Tulane University School of Medicine, New Orleans, LA, 8Department of Neurology, Tulane University School of Medicine, New Orleans, LA, USA, 9Department of Anatomical Sciences, St. George’s University, St. George’s, Grenada, 10Department of Surgery, Tulane University School of Medicine, New Orleans, LA, USA, 11University of Queensland, Brisbane, Australia

Correspondence to:Juan J. Cardona
Department of Neurological Surgery, Tulane Center for Clinical Neurosciences, Tulane University School of Medicine, 131 South Robertson St. Suite 1300, New Orleans, LA 70112, USA
E-mail: jcardona2@tulane.edu

Received: March 24, 2023; Revised: May 13, 2023; Accepted: July 9, 2023

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The carotid sinus nerve (CSN) is well known as mediating baroreflexes. However, studies of its detailed histological analysis are scant in the literature. Therefore, the current anatomical study sought to better elucidate the microanatomy of the CSN. Ten fresh frozen adult cadavers underwent dissection of the CSN. Then, it was harvested and submitted for histological and immunohistochemical staining. Specimens were all shown to be nerve fibers on histology and immunohistochemistry. We identified tyrosine hydroxylase positive fibers in all CSN specimens. These fibers were always found to be within the CSN and not on its surface i.e., epineurium. Based on our findings, the majority of fibers contained in the CSN are tyrosine positive in nature. Further studies are necessary to understand the true function of this autonomic nerve fibers.

Keywords: Carotid sinus nerve, Histology, Immunohistochemistry, Nerve stimulation, Anatomy

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