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open access eISSN 2093-3673

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Review Article

Anat Cell Biol 2022; 55(1): 14-19

Published online March 31, 2022


Copyright © Korean Association of ANATOMISTS.

Role of macrophages in liver cirrhosis: fibrogenesis and resolution

Sherine Ahmed Elsherif1,2 , Ahmed Salah Alm2

1Histology Department, Faculty of Medicine, Sohag University, Sohag, 2Histology Department, Faculty of Medicine, Merit University, Sohag, Egypt

Correspondence to:Sherine Ahmed Elsherif
Histology Department, Faculty of Medicine, Sohag University, Sohag 000, Egypt
E-mail: loua.sherine@yahoo.com

Received: March 2, 2021; Revised: May 20, 2021; Accepted: September 10, 2021

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


At present, chronic liver disease accounts for approximately 2 million deaths per year worldwide. Liver injury induces a series of events causing inflammation. Chronic inflammation ends in liver fibrosis. A stage of fibrinolysis occurs on stopping insult. Kupffer cells play their role to initiate inflammatory responses, while infiltrating monocyte-derived macrophages have a role both in chronic inflammation and fibrosis and in fibrosis resolution. Ly-6C high expressing monocytes act during fibrogenesis, while Ly-6C low expressing monocytes are restorative macrophages which promote resolution of fibrosis after end of the injury. Recent studies have identified new phenotypes, such as metabolically activated M, oxidized, which may have a role in fatty liver diseases.

Keywords: Liver cirrhosis, Macrophages, Fibrosis, Liver cirrhosis, Macrophages

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