Anat Cell Biol 2021; 54(2): 292-296
Published online June 30, 2021
Copyright © Korean Association of ANATOMISTS.
1Ministry of National Defense Agency for KIA Recovery & Identification, Seoul, 2Institute of Forensic and Anthropological Science, Seoul National University College of Medicine, Seoul, 3Department of Radiology, Seoul National University College of Medicine, Seoul, 4Department of Radiology, Seoul National University Hospital, Seoul, 5Department of Research and Development, MEDICALIP Co. Ltd., Seoul, 6Laboratory of Bioanthropology, Paleopathology and History of Diseases, Department of Anatomy, Seoul National University College of Medicine, Seoul, Korea
Correspondence to:Hyejin Lee
Ministry of National Defense Agency for KIA Recovery & Identification, Seoul 06984, Korea
Dong Hoon Shin
Institute of Forensicand Anthropological Science, Seoul National University College of Medicine, Seoul 03080, Korea
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Since the first description of this disease in 1887, there are rare reports on osteochondrosis dissecans (OCD) found in the glenoid cavity by way of anthropological studies. During an excavation project for recovery of the remains of Korean War casualties, a skeletonized soldier was found inside a cave fort at the Arrowhead Ridge of the demilitarized zone (DMZ), South Korea. In our recovery and examination of a Korean War casualty in DMZ, we identified a possible OCD in the individual’s glenoid cavity of a right-sided scapula by radiological analysis and computed tomography reconstruction. This is a rare case of scapular OCD discovered in an archaeologically investigated skeleton.
Keywords: Archaeology, Anthropology, Osteochondritis dissecans, Radiology
Osteochondritis (or osteochondrosis) dissecans (OCD) is an acquired or idiopathic inflammatory joint disease that causes focal changes in articular cartilage. The etiology of OCD is likely related to strenuous activity, trauma, genetic factors, avascular necrosis, endochondral ossification abnormality, or fat emboli. It induces a detachment or separation of subchondral bone or cartilaginous segments from the underlying bones . It finally leaves either a stable or somewhat unstable bony fragment inside the knee, ankle, or elbow joint .
OCD has been reported in archaeological skeletons . During the research on the Late Holocene skeletons from Southern Patagonia, OCD cases possibly due to strenuous physical activity were found (Zúñiga Thayer et al., 2020) . In Anderson’s research  on medieval-to-post-medieval skeletons rescued from San Pietro Barisano Church, the child case exhibited a circular defect in the cuboid bone, a possible sign of OCD. The same author also had reported OCD cases from medieval skeletons excavated at Norwich, England . When Vikatou et al.  examined 19th century skeletons from Middenbeemster (the Netherlands), they found that pedal OCD prevalence was distinctly high among the cases, probably due to repetitive trauma incurred by the hard physical labor entailed in raising livestock. Pany-Kucera et al.  reported an OCD case in subadult skeletons from the Iron Age Hallstatt graveyard.
Nevertheless, reports of OCD from archaeologically investigated skeletons remain rare. This is understandable, as OCD prevalence in human populations generally is very low (<1%). Especially in East Asia, there have been no anthropological reports of OCD found in any archaeologically obtained human bones. Recently, we examined over 300 Korean war casualties’ skeletons found in the demilitarized zone (DMZ). During our forensic examination of the skeletons, we found an anthropologically significant case manifesting possible signs of OCD in the glenoid cavity of the scapula.
In 2018, an excavation project for recovery of the remains of war casualties was initiated in the region of the DMZ. The Battle of Arrowhead Ridge (1952–1953), an engagement of the Korean War, resulted in approximately 4,000 soldiers killed or missing in action. The excavation site is a cave fort at the top of Arrowhead Ridge (Fig. 1). A skeletonized soldier (Case no. 20-DMZ-28) was found inside a cave fort lying in prone position (face down) (Fig. 2). He wore combat boots on both feet; a belt and buckle were found in the pelvic area. Hand grenades (MK2) were discovered beside both of his arms. The individual's skeletal remains were moved to the headquarters of the Ministry of National Defense Agency for KIA Recovery & Identification (MAKRI, Seoul, Korea).
To estimate a biological profile of the soldier, we followed the standard bioanthropological procedures of Buikstra et al. . Age was estimated by degenerative changes in osteology and dental attrition . In brief, the skeleton was determined to be that of a male by the shape of the pelvic bone. His ancestry was presumed to be an Asian based on the morphologies of the nose, nasal aperture, and projecting zygomatic process of the facial bones. As for the age estimation, we note that most of the long-bone epiphyses were completely fused, but no degenerative changes were observed in the joints. The degree of dental attrition was B1-B2 by Lovejoy et al.’s method . Age estimation by teeth indicated that the individual had been between 16 and 20 years old. We used the estimation formula for an East Asian male’s stature introduced by Trotter and Gleser . His height was estimated to have been approximately 167.2 cm. We examined the teeth for carious and other pathological lesions with a magnifying glass. Caries was observed in a tooth (right upper first molar), forming small cavities around the occlusal surface. Calculus was deposited in the posterior teeth (premolars and molars).
Anthropological examination was also performed for the right-sided scapula of the individual. In the scapula of the soldier, we found a possible sign of OCD (Fig. 3). In brief, an intra-articular bony fragment was found at the center of the glenoid cavity; and around it, the bony defect, possibly an infarcted area, could be identified as well. On the glenoid cavity surface, the concentric bony fragment appeared to be separated from the underlying bone; but a part of it was still attached to the bone, given its stable fixation on the scapula. Around the bony fragment, there was a concave defect with steep-sided edges as described in a previous report of OCD . The lesion appeared to represent phase IIb among the OCD stages proposed by Bohndorf . That is, the bony fragment was mostly demarcated by the defect around it; but the separation of the osseous part from its bed was not complete. In case of left-sided scapula, however, we could not find similar signs of OCD on the glenoid cavity surface.
To see the separation pattern of the bony fragment more clearly, we used radiological tools. A plain X-ray on the scapula was taken at MAKRI headquarters. On the plain X-ray radiography, the concentric bony fragment could be seen; however, its separation (the presumed radiolucency around it) was not clearly identifiable (Fig. 4A). We thus performed the computed tomography (CT) analysis on the soldier’s scapula. A CT scan was conducted at the National Forensic Service Seoul Institute (Seoul, Korea). The CT radiological data were obtained by a 128-slice multidetector CT (MDCT) scanner (175 mA, 120 kV, 0.6 mm slice thickness; SOMATOM Definition AS+, Siemens, Munich, Germany). For 3-dimensional (3D) reconstruction, stand-alone medical 3D segmentation & modeling software (MEDIP Pro v2.1.3; MEDICALIP, Seoul, Korea) was used. In the cross-section CT image, we found the bony fragment in the scapula along with a concave defect with steep-sided edges (Fig. 4B). In the 3D-reconstruction of the CT images (Fig. 5A), the bony fragment and concave defect were clearly evident (Fig. 5B). The concave defect separated the bony fragment from the surrounding scapula. Nonetheless, the separation was not perfect, as a part of the bony fragment remained attached to the surrounding bone (Fig. 6). Fig. 7 exhibits the incomplete separation of the bony fragments from the concave defect around it. Judging from these radiological findings, we confirmed that this was likely a case of phase IIb of OCD .
Among several diseases similar to OCD, old osteochondral fracture is likely the most difficult to distinguish from it . In general, OCD is known as an acquired lesion in the subchondral bone, characterized by osseous collapse, resorption, and the formation of sequestrum with the involvement of the cartilage that is unrelated to fractures in osteochondral parts . To confirm whether a case is OCD, clinicians usually try to find clinical signs such as chondral separation, chondral flaps, or hemarthrosis. However, these signs are not useful for diagnosis of OCD in human bones obtained from archaeological sites. Differential diagnosis of OCD lesions in archaeological skeletons is certainly not easy.
In this context, anatomical and radiological examinations must proceed cautiously so as to successfully confirm OCD in anthropological cases. For example, OCD must be carefully differentiated from osteochondral fracture fragment, which is characterized as a flat surface related to a tangential injury. OCD, meanwhile, has a defect with characteristic steep-sided edges around the bony fragment, which was also evidenced in the present case by our anatomical as well as radiological examinations. Moreover, the soldier, as noted earlier, was likely to have been an adolescent or young male aged 16–20 years, which finding also is consistent with a known characteristic of OCD . Taking all of evidence together, we could conclude that our skeleton is a case of OCD occurring in the glenoid fossa of a Korean War casualty’s scapula.
This report is significant to anatomists, considering that there have been only a few articles reported OCD involving any human bones unearthed at excavation sites [4-8]. Our case is unique also in that osteochondral lesion rarely involves the shoulder . This is the first report on OCD in the shoulder joint of an archaeological skeleton.
According to Andriolo et al. , OCD’s etiology is largely attributed to two causal factors: biological and mechanical. With respect to the second, our young soldier was confirmed to have died in the course of a major battle of the Korean War, and as such, was very likely to have been subject to intense physical exertion, and even trauma, at that time. Actually, OCD was not rarely reported in modern arthroscopic surgery on military troops during Operation Desert Shield (Buckley et al., 1992) . These, exertion and trauma, can thus be considered to be the most likely mechanical OCD-inducing factors in our particular case. Nevertheless, we also note that the etiology of OCD includes genetic factors, avascular necrosis, endochondral ossification abnormality, or fat emboli . These factors cannot be entirely ruled out from the possible causes of OCD found in the soldier’s scapula even if that possibility is likely low compared to exertion and trauma.
This work was supported by the Ministry of Science and ICT of the Republic of Korea and the National Research Foundation of Korea (NRF-2019S1A5C2A01083578). The authors express sincere condolences to the families and/or descendants of soldiers killed or missing in action at Arrowhead Ridge during the Korean War. We specially thank Drs. Won-Joon Lee, Se-Min Oh, and Ji-Hwan Park of the National Forensic Service Seoul Institute for their generous help during CT scanning.
Conceptualization: HL, DHS. Anthropological data analysis: HL, KK, MC, TN, JEK, DHS. Radiological data analysis: SJP, DHL. Drafting and revision of the manuscript: HL, DHS. Approval of the final version of the manuscript: all authors.
No potential conflict of interest relevant to this article was reported.