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Anat Cell Biol

Published online September 3, 2020

https://doi.org/10.5115/acb.19.181

Copyright © Korean Association of ANATOMISTS.

Tumor associated mast cells: biological roles and therapeutic applications

Shikha Saxena1 , Anil Singh2 , Priyanka Singh3

1Department of Oral Pathology, RUHS College of Dental Sciences (Government Dental College), Jaipur, Rajasthan, 2Department of Oral Pathology, Saraswati Dental College and Hospital, Lucknow, Uttar Pradesh, 3Department of Oral Pathology, Faculty of Dental Sciences, King George Medical University, Lucknow, Uttar Pradesh, India

Correspondence to:Shikha Saxena
Department of Oral Pathology, RUHS College of Dental Sciences (Government Dental College), Jaipur, Rajasthan 302017, India
E-mail: drshikhasaxena29@gmail.com

Received: August 16, 2019; Revised: July 17, 2020; Accepted: August 5, 2020

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Mast cells (MCs) are immune cells of the myeloid lineage and are present in connective tissues throughout the body. The activation and degranulation of MCs significantly modulates many aspects of physiological and pathological conditions in various settings. Recent data have expanded the concept that inflammation is a critical component for tumor progression. Interestingly, three of the most aggressive human cancers, malignant melanoma, breast carcinoma and colorectal adenocarcinoma, are commonly associated with a marked host response comprising of various inflammatory cells, but especially MCs around the tumor periphery. A systematic review of the literature was performed based on the English titles listed in the PubMed, EBSCO, Cochrane, Science Direct, ISI web Science, and SciELO databases using the keywords. Abstracts and full-text articles were assessed. This review summarizes the current understanding of the role of MCs in tumor progression.

Keywords: Mast cell activation, Development, Proliferation, Migration, Survival

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