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pISSN 2093-3665 eISSN 2093-3673
Fig. 6.
Fig. 6. (A) Photomicrographs of the of CA3 region of the hippocampus control group showing compact layers of small granular and pyramidal cells most with vesicular nuclei. Each neuron features a large nucleolus and a rounded central vesicular nucleus (arrows). (B) I/R micrograph showed marked neuronal degeneration with PC, K, DN, CV, PV in the histoarchitecture of the hippocampus. (C) I/R+50 mg/kg MNC group showed preservation of pyramidal cells with few pyknotic and degenerating neurons and mild clumping of granular cells. (D, E) I/R-induced ischemic stroke & treatment with PTT (100/200 mg/kg) group, showing improvement in the histoarchitecture of the hippocampal pyramidal and granular cells at CA1 and CA3 region (H&E, ×250). (F) is a graph of the stereological estimate of the hippocampal CA3 pyramidal cell number across the group. n=5; mean±SEM, one-way ANOVA, Tukey’s post-hoc test. CA1, cornu ammonis 1; CA3, cornu ammonis 3; G, granular cells; K, karyorrhexis; PV, perineural vacuolation; DN, dark neuron; CV, cytoplasmic vacuolation; PC, pyknotic cell; I/R, ischemia/reperfusion; MNC, minocycline; PTT, phenolics fraction of Tetrapleura tetraptera. aP<0.05 when compared to the control group, bP<0.05 when compared to the I/R group.
Anat Cell Biol 2024;57:543~558 https://doi.org/10.5115/acb.24.013
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