Fig. 3. Elevated plus maze test (A, B) and open field (C, D) result. The results of these test showed that 3-NP administration significant decrease in OAT and OAE (***P<0.001). The elevated plus maze test in Huntington’s disease (HD) group exhibit increased anxiety-like behavior (decreased distance travelled and time in center) in comparison with control group (***P<0.001). Open field result showed the Apelin-13 decrease distance travelled and time in center comparison to the control group (***P<0.001).
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