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Fig. 4.
Fig. 4. Astrogliosis of the SNpc. (A) immunostaining for GFAP in the midbrain (scale bar=50 µm), slide: PBS (PBS group) depicted fewer astrocytes; MPTP (MPTP group) exhibited notably numerous reactive astrocytes (red arrows); levodopa (levodopa group) and honey (honey group) showed only a few astrocytes; honey & MPTP (honey & MPTP group) and levodopa & MPTP (levodopa & MPTP group) displayed fewer reactive astrocytes compared to the MPTP group. (B) GFAP+ cell count. The cells identified as astrocytes are GFAP-positive (GFAP+ cells). a,b,dSignify significant differences compared to PBS, MPTP, and honey groups respectively, at P<0.05; n=6. PBS, MPTP, levodopa, honey, honey & MPTP, levodopa & MPTP stands for the mice that received, PBS. MPTP, honey, honey & MPTP, and levodopa & MPTP respectively. SNpc, substantia nigra pars compacta; GFAP, glial fibrillary acidic protein; PBS, phosphate buffered saline; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Anat Cell Biol 2024;57:431~445 https://doi.org/10.5115/acb.24.034
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