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Fig. 2.
Fig. 2. Nissl substance of SNpc neurons. (A) CFV stained sections of the midbrain (scale bar=10 µm), slide; PBS (PBS group) showed neurons with intact Nissl bodies (black arrows); MPTP (MPTP group) exhibits neurons with pale cytoplasm, indicating Nissl body loss (red arrows); levodopa (levodopa group) displayed neurons with intact Nissl bodies (black arrows); honey (honey group) showed deeply stained neurons with intact Nissl bodies (black arrows); honey & MPTP (honey & MPTP group) depicts mostly intact Nissl bodies (black arrows), with a few lost ones; levodopa & MPTP (levodopa & MPTP group) presents neurons with well-stained cytoplasm indicating intact Nissl bodies (black arrows) and some pale neurons (red arrows). (B) Chromatolytic cell count. A neuron is deemed chromatolytic when it loses its Nissl bodies. a,b,dIndicate significant differences compared to PBS, MPTP, and honey groups respectively, at P<0.05; n=6. PBS, MPTP, levodopa, honey, honey & MPTP, levodopa & MPTP stands for the mice that received, PBS. MPTP, honey, honey & MPTP, and levodopa & MPTP respectively. SNpc, substantia nigra pars compacta; CFV, cresyl fast violet; PBS, phosphate buffered saline; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Anat Cell Biol 2024;57:431~445 https://doi.org/10.5115/acb.24.034
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