Fig. 4. Micrographs of rat’s ovaries after Ki-67 immunohistochemical technique. Ki-67-strongly stains the cell nuclei (A–D). (A) The control group, granulosa cells and theca cells in the graafin folliciles (GF) are intensely stained. (B) The SOF-treated group demonstrates Ki-67-negativily stained cystic atretic follicles (CF), (C) The Vit E-treated group, and (D) the SOF+Vit E-treated group, where the number of Ki-67-positive cells localized in granulosa and theca cells of GF. (E) Histogram illustrates the quantitative analysis of the intensity of Ki-67 stain area percentage in different experimental groups. The SOF-treated group demonstrates a statistically significant reduction compared to the control group, *P<0.01, ****P<0.00001. The SOF+Vit E Co-treatment reduces Ki-67 immuno-staining significantly in comparison with the SOF treated group, ####P<0.00001 (Bar=20 μm). SOF, Sofosbuvir; Vit E, vitamin E.
© Anat Cell Biol
pISSN 2093-3665
eISSN 2093-3673
