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pISSN 2093-3665 eISSN 2093-3673
Fig. 1.
Fig. 1. Histograms showing the mean ovarian tissue oxidative stress markers (NO, MDA, SOD, GSH, and CAT). (A, B) Levels of NO and MDA in different experimental groups were demonstrated. The SOF-treated group shows a significant upregulation in the level of NO and MDA compared to the control group, ****P<0.00001. The oxidative stress markers’ levels are reversed considerably in the SOF+Vit E-treated group compared to the SOF group, ###P<0.0001, ####P<0.00001. (C–E) The ovarian tissue CAT, SOD, and GSH levels in different experimental groups. The SOF-treated group demonstrates a significant downregulation in CAT, SOD, and GSH levels compared to the control group, ***P<0.0001, ****P<0.00001. The oxidative stress markers are considerably altered in the SOF+Vit E co-treated group compared to SOF group, #P<0.01 and ###P<0.0001. One-way ANOVA was used to compare between all the groups, unpaired t-test was used to compare each group with the control, and the SOF+Vit E co-treated with SOF group. NO, nitric oxide; MDA, malondialdehyde; SOD, super oxide dismutase; GSH, reduced glutathione; CAT, catalase; SOF, Sofosbuvir; Vit E, vitamin E. *P<0.01 and **P<0.001.
Anat Cell Biol 2023;56:526~537
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