Anatomy & Cell Biology

Table 1

Summary of frequently mutated genes in each LCSC group

Markers	Frequently mutated genes
CD133	IRF2, TRRAP, ASXL2, FGFR2, TLE4, BAP1, MECOM, PBRM1, NOTCH1, ERBB3
CD44	JAK1, PIK3C2G, PTPRD, ATP1A1, KMT2A, POLQ, JAK3, NF1, ATXN7, STAT3
CD24	CDH1, ERBB3, FLT1, HIRA, BAP1, IDH1, CLTCL1, NFATC2, HIP1, CPS1
CD47	SOS1, IDH1, NUMA1, TSC2, NCOA3, CDH11, AFF1, ASXL2, PLCG1
CD13	BRCA2, NSD1, KDM4C, BAX, HSP0AA1, BAP1, PTPN13, TEK, MYH11, KDR, RAD50, RB1
CD90	CPS1, PAX3, CUX1, PTPRK, EPHA7, FOXP1, BAP1, CAMTA1, CDH1, ERBB3, WDR90
ICAM1	TSC2, CDH11, TLX3, SETD2, NFATC2, CHD4, NOTCH3, JARID2, KMT2C, ASXL2
EpCAM	BAP1, NOTCH2, TLX3, CTCF, ASXL2, IRF2, DNMT3A, SMAD4, TEK, PED4DIP, RASA1, COL2A1
LGR5	EP300, DNMT3A, GMPS, EPHA5, CTNNB1, RELN, IL6ST, ROBO1, KIT, COL2A1
KRT19	IFR2, TLX3, NOTCH2, ERBB3, BAP1, CPS1, EPHB1, BCL11B, NFATC2, TET3

LCSC, liver cancer stem cell; CD, cluster of differentiation; ICAM1, Intercellular adhesion molecule 1; EpCAM, epithelial cell adhesion molecule; LGR5, leucine-rich repeat-containing G protein-coupled receptor 5; KRT19, keratin 19.

Anat Cell Biol 2023;56:94~108 https://doi.org/10.5115/acb.22.161