pISSN 2093-3665
eISSN 2093-3673
pISSN 2093-3665
eISSN 2093-3673
Similarities and differences between VEC and LEC [39-46]
| Common features | VEC | LEC |
|---|---|---|
| Barrier function, vasomotor tone, vascular permeability regulation, tissue vascularization, and immune response | Regulation of coagulation | Semi-professional antigen-presenting, B-cell homing to lymph nodes via CXCL13 expression |
| Peroxisome proliferator-activated receptor delta H2S | ||
| Surface receptor: | Surface receptor:endothelial receptors FcRn, VEGFR2, vascular endothelial protein tyrosine phosphatase, receptor for vascular endothelial growth factor Flk1, receptor for sphingosine-1-phosphate 1, NLRP6, TGF-β receptor, Thromboxane A2 receptor, angiotensin II receptor (AT1), scavenger receptor class B type I, G protein-coupled receptor 68, histamine receptor (H1), tyrosine kinase Tie2 bradykinin receptor (B2), vitamin D endothelial receptor, albondin (gp60), FGFR2, serotonin receptor (S1), ET-1 receptor (ET-B), ADP and ATP receptor, DCC/neogenin and UNC5 receptors of netrin-1, Natriuretic peptide receptor A, B, and C | Surface receptor: VEGFR-3, IL-1, IL12, IL18, IL27 receptors, C-type lectin receptor, Fc receptor (FCGR2B), LYVE-1, sigma receptor-1, Natriuretic peptide receptor D, scavenger receptors; MSR-1 (SR-A1), MARCO (SR-A6), STAB-2 (SR-H2), and CXCL16 (SR-G1) |
| G-coupled protein receptor, TLR 4, NLR, IL-10 receptor, sphingosine-1-phosphate and prostaglandins receptors, transient receptor potential, ephrin A, ephrin B2 and EphB4, neuropilins (accessory), Acetylcholine receptor (M1-5), Endoglin, scavenger receptors; CD36 (SR-B2) and SCARF-1 (SR-F1) | ||
| Released molecules: endothelin, prostacyclin I2, nitric oxide, urotensin, CNP, adenosine, purines, reactive oxygen species, H2S | ||
| Induce angiogenesis by CD112 (nectin-2), netrin-1, FGF-2, TGF-β, TNF-α, IGF-1, and VEGF | Released molecules: protein c and s, thrombomodulin, calmodulin, tissue-type plasminogen activator, plasminogen activator inhibitor type-I, platelet-activating factor, Von Willebrand factor, adrenomedullin | MAFB transcription factor overexpressed |
| MHC-II, H-2DMα, and H-2DMβ overexpression | 208 difference in the expressed genes (NRCAM, TAGLN, CD44, FSTL1, IL8, AUTS2, CXCL1, RNASE1, LTBP2, MCAM, AXL, DSG1, CAP2, ITGA5, ZNF207, FAP, ITGA4, PLA2G4A, BMP6, VAMP8, ACTA2, GPR39, ISG15, VCAN, RGS5, KRT7 COL6A3, DKK1, CXCR4, SEC, 61B, LPHN2, IL13RA2, IFI27 , SRGN, GLIPR1, SELP, FBLN5, IL4R, SH3BP4, TPM2, BMP1, FLT1, EMP3, SERPINE1, CSF2RB, PCDH1, TSPAN3, IGF2BP3, ITGB3, VEGFC, HOXB, PLAU, VWF, CDH2, JAM3 PFN2, F2R, COL1A2, NCL, CHST1, ESM1, PGF, RP3-523C21.1, MMP1, EFEMP2, CCL2 CCT5 BASP1, CD93, C17orf72, ICAM2, SHISA3, MLLT11, SPARC, ITGB5, MCTP1, CLU, LAMC1, LAMB2, CCRL2, GATA6, TGFBI, PECAM1, COL6A1, C1orf54, IL6, FN 1, TRIM22, LAMB1) | 155 difference in the expressed genes (PROX-1, GMFG, CEACAM1, CXCL12, PVRL3, RBP1, F2RL1, PDPN, FABP4, MRC1, MRC1L1, TNFSF10, MAF, LGALS8, RELN, PPARG, CALCRL, HSD17B2, CH25H, PSMG1, MGP , TFF3 CD36, SEPP1, CCL5, ANGPT2, ID1, SLC26A4, JUP, DSP, SNRNP48, ADRB1, RGS16, GLRB, NID1 ITGA9, THBS1, LAYN, CDKN1C, HMMR, ADAMTSL3, CRMP1, IL6ST, SNAI2, PCSK6, JAG1, EPS8 ITGA1, CCL20, AK5, MEF2C, TGFA, RP11-65D13.1, APOD, FGF12, FDFT1, PDLIM3, ITGA6, GRAMD3, CCNE2, MFAP3, COLEC12, TIMP3, GHR, CD200, HEY1, ADD3, GYPC, TK1, TFPI, LIPA) |
| 4oo differences in the expressed genes |
VEC, vascular endothelial cells; LEC, lymphatic endothelial cells; TLR 4, toll-like receptors; NLR, nod-like receptor; TNF-α, tumor necrosis factor-α; VEGFR-3, vascular endothelial growth factor receptor-3; LYVE-1, lymphatic vessel endothelial hyaluronan receptor-1.
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