Fig. 6. Photomicrograph of COX-2 immunostaining (×400) showing: (A) Control group: minimal COX-2+ve immunostaining in gastric mucosa. (B) CRS: minimal+ve immunostaining at the edge of the ulcer. (C) Ran+CRS: enhanced COX-2+ve immunostaining in the glandular epithelium and stromal cells. (D) Sim+CRS: moderate COX-2+ve immunostaining in the gastric mucosa. (E) Neb+CRS: moderate COX-2+ve immunostaining in the gastric mucosa. (F) Sim+Neb+CRS: marked increase COX-2+ve immunostaining in gastric mucosa. COX-2, cyclooxygenase 2; CRS, cold restraint stress; Neb, nebivolol; PAS, periodic acid Schiff’s; Ran, ranitidine; Sim, simvastatin. Scale bars=20 µm (A–F).
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